Reaktion #327784

Reaktionsgleichung

Methansulfonyl chloride

3-pyrrolidinol

triethylamine

→

1-(Methylsulfonyl)pyrrolidin-3-yl methansulfonate

Lösungsmittel

dichloromethane

Reaktionsbedingungen

Aufarbeitung

1. 1
   SonstigeAfter 10 mins the coolant was removed
2. 2
   WaschenThe mixture was washed with 10% KHSO4 and 10% aq. K2CO3
3. 3
   Sonstigethe solvent was evaporated

Vorschrift

Methansulfonyl chloride (1.93 ml) added to an ice cooled solution of 3-pyrrolidinol (871.0 mg) and triethylamine (3.47 ml) in dichloromethane (30.0 ml). After 10 mins the coolant was removed and the mixture was stirred at room temperature for 2 h. The mixture was washed with 10% KHSO4 and 10% aq. K2CO3. The organic layer was passed through a hydrophobic frit and the solvent was evaporated.

Quelle