Reaktion #326921

Reaktionsgleichung

2,3-dimethylcyclohexylamine

1,3-propane sultone

→

3-(2,3-dimethylcyclohexyl)amino-1-propanesulfonic acid

Lösungsmittel

tetrahydrofuran

THF

Reaktionsbedingungen

Aufarbeitung

1. 1
   Temperaturat reflux for 2 hours
2. 2
   FiltrationThe solid was collected by filtration
3. 3
   Waschenwashed with THF (50 mL) and acetone (50 mL)
4. 4
   workup.DISSOLUTIONThe solid was dissolved in 25% EtOH/water (150 mL)
5. 5
   workup.ADDITIONtreated with Dowex 50WX8 resin (15 g)
6. 6
   workup.STIRRINGThe suspension stirred at room temperature for 5 minutes
7. 7
   SonstigeThe resin was removed by filtration
8. 8
   EinengenThe filtrate was concentrated to dryness under reduced pressure
9. 9
   FiltrationThe solid material was collected by filtration
10. 10
    Sonstigedried in vacuo

Vorschrift

To a solution of 2,3-dimethylcyclohexylamine (10.0 g, 79.0 mmol) in tetrahydrofuran (60 mL) was slowly added a solution of 1,3-propane sultone (9.3 g, 75.0 mmol) in THF (20 mL). The solution was stirred at reflux for 2 hours. The reaction mixture was cooled to room temperature. The solid was collected by filtration, washed with THF (50 mL) and acetone (50 mL). The solid was dissolved in 25% EtOH/water (150 mL), and treated with Dowex 50WX8 resin (15 g). The suspension stirred at room temperature for 5 minutes. The resin was removed by filtration. The filtrate was concentrated to dryness under reduced pressure; and the solid residue was suspended in acetone (100 mL). The solid material was collected by filtration, and dried in vacuo; affording compound DK (7.4 g, 43%). 1H NMR (D2O, 500 MHz) 8 ppm 3.29 (m, 0.5H), 3.09 (m, 2H), 2.88 (t, 2H, J=7.3 Hz), 2.80 (m, 0.5H), 1.99 (m, 3H), 1.40 (m, 7H), 0.81 (m, 6H). 13C NMR (D2O, 125 MHz) 8 ppm 62.85, 61.56, 59.88, 58.22, 48.26, 48.15, 44.29, 43.84, 43.59, 42.65, 42.01, 41.03, 37.34, 36.12, 34.73, 34.45, 33.88, 33.64, 29.39, 28.00, 26.50, 24.25, 24.02, 23.64, 22.42, 21.55, 21.45, 21.35, 19.38, 19.13, 18.82, 18.40, 14.38, 13.39, 4.59. ES-MS 248 (M−1).

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