Reaktion #325994

Reaktionsgleichung

3-bromo-5-fluorophenol

1,2-dibromotetrafluoroethane

DMSO

Cs2CO3

→

1-bromo-3-(2-bromo-1,1,2,2-tetrafluoroethoxy)-5-fluorobenzene

Ausbeute 94.0%

Lösungsmittel

hexane

water

Reaktionsbedingungen

Aufarbeitung

1. 1
   SonstigeTo a flame dried
2. 2
   Sonstige1 L, three necked round bottom flask (1 L) equipped with a temperature controller, a mechanical stirrer, a condenser and a N2 inlet
3. 3
   TemperaturAfter cooling to rt
4. 4
   SonstigeThe organic phase was separated
5. 5
   Extraktionthe aqueous layer was extracted with hexane (300 mL)
6. 6
   WaschenThe combined organic extracts were washed with water (500 mL), sat. NaCl (500 mL)
7. 7
   Trocknendried over MgSO4
8. 8
   Filtrationfiltered
9. 9
   Einengenconcentrated in vacuo

Vorschrift

To a flame dried, 1 L, three necked round bottom flask (1 L) equipped with a temperature controller, a mechanical stirrer, a condenser and a N2 inlet was charged 3-bromo-5-fluorophenol (57.3 g, 300 mmol), 1,2-dibromotetrafluoroethane (156.0 g, 600 mmol), dry DMSO (300 mL) and Cs2CO3 (146.6 g, 450 mmol) under N2. The reaction mixture was heated to 50° C. for 5 h. After cooling to rt, water (300 mL) and hexane (300 mL) were added. The resulting mixture was stirred at rt for 30 min. The organic phase was separated and the aqueous layer was extracted with hexane (300 mL). The combined organic extracts were washed with water (500 mL), sat. NaCl (500 mL), dried over MgSO4, filtered and concentrated in vacuo to give 1-bromo-3-(2-bromo-1,1,2,2-tetrafluoroethoxy)-5-fluorobenzene (104.2 g, 94% yield) containing 5% of 1-bromo-3-fluoro-5-(1,1,2,2-tetrafluoroethoxy)benzene (5.2 g). 1-Bromo-3-(2-bromo-1,1,2,2-tetrafluoroethoxy)-5-fluorobenzene: 1H NMR (300 MHz, CDCl3) δ 6.91-6.94 (m, 1H), 7.18-7.23 (m, 2H).

Quelle