Reaktion #3256

Reaktionsgleichung

5-cyano-4-hydroxy-2-methylsulfanylpyrimidine

5-cyano-4-hydroxy-2-methylsulfanyl-pyrimidine

phosphorus oxychloride

→

title compound

4-Chloro-5-cyano-2-methylsulfanyl-pyrimidine

Reaktionsbedingungen

Aufarbeitung

1. 1
   Temperaturwas heated
2. 2
   Temperaturat reflux for 3 hours
3. 3
   Filtrationfiltered
4. 4
   Einengenthe filtrate was concentrated to dryness under vacuum
5. 5
   SonstigeThe residue was partitioned between methylene chloride and ice water
6. 6
   SonstigeThe organic layer was separated
7. 7
   Waschenwashed with water
8. 8
   Trocknendried over magnesium sulfate
9. 9
   Filtrationfiltered
10. 10
    Sonstigeevaporated under reduced pressure
11. 11
    TemperaturThe residue was heated
12. 12
    Temperaturto reflux in hexane (750 mL)
13. 13
    SonstigeThe hot hexane solution was decanted from the insoluble material
14. 14
    Temperaturto cool to room temperature

Vorschrift

A mixture of 5-cyano-4-hydroxy-2-methylsulfanylpyrimidine (48.33 g) from Example 1 and phosphorus oxychloride (150 mL) was heated at reflux for 3 hours. The reaction mixture was allowed to cool to room temperature, filtered, and the filtrate was concentrated to dryness under vacuum. The residue was partitioned between methylene chloride and ice water. The organic layer was separated, washed with water, dried over magnesium sulfate, filtered, and evaporated under reduced pressure. The residue was heated to reflux in hexane (750 mL) with stirring. The hot hexane solution was decanted from the insoluble material and allowed to cool to room temperature to afford 32 g of the title compound 4-chloro-5-cyano-2-methylsulfanyl-pyrimidine.

Quelle