Reaktion #325446

Reaktionsgleichung

methanol

1-benzyl-4-fluoro-4-phenyl-piperidine

1-chloroethylchloroformate

→

title compound

Ausbeute 55.0%

1-Benzyl-4-phenyl-piperidin-4-ol

Ausbeute 55.0%

Lösungsmittel

DCM

Reaktionsbedingungen

Aufarbeitung

1. 1
   workup.STIRRINGthe mixture stirred overnight
2. 2
   SonstigeThe solvent was removed under vacuum
3. 3
   Sonstigethe resulting solid triturated from diethyl ether

Vorschrift

To 1-benzyl-4-fluoro-4-phenyl-piperidine (0.22 g) in dry DCM (5 mL) was added 1-chloroethylchloroformate (1 mmol). The mixture was stirred for 1 hour and then methanol (5 mL) was added and the mixture stirred overnight. The solvent was removed under vacuum, and the resulting solid triturated from diethyl ether to give the title compound as a white solid (0.12 g). LCMS m/z 180.1 [M+H]+. R.T.=2.27 min (Analytical Method 4).

Quelle