Reaktion #325444

Reaktionsgleichung

4-Hydroxy-4-phenylpiperidine

benzylbromide

potassium carbonate

→

title compound

Ausbeute 62.8%

1-Benzyl-4-phenyl-piperidin-4-ol

Ausbeute 62.8%

Lösungsmittel

DMF

ethyl acetate

Reaktionsbedingungen

Aufarbeitung

1. 1
   Waschenwashed with a solution of saturated aqueous sodium carbonate solution
2. 2
   Trocknenthen dried over magnesium sulphate
3. 3
   Filtrationfiltered
4. 4
   Sonstigethe solvent removed by evaporation under vacuum
5. 5
   SonstigeThe resulting solid was recrystallised from pentane

Vorschrift

4-Hydroxy-4-phenylpiperidine (0.5 g, 2.8 mmol), benzylbromide (0.5 g, 3 mmol) and potassium carbonate (0.8 g, 6 mmol) were dissolved in DMF (5 mL) and stirred for 2 hours. The mixture was diluted with ethyl acetate and washed with a solution of saturated aqueous sodium carbonate solution then dried over magnesium sulphate, filtered and the solvent removed by evaporation under vacuum. The resulting solid was recrystallised from pentane to give the title compound as a white solid (0.47 g). LCMS m/z 268.3 [M+H]+. R.T.=2.37 min (Analytical Method 4).

Quelle