Reaktion #325233

Reaktionsgleichung

5-iodo-7-methyl-7H-pyrrolo[2,3-d]pyrimidin-4-amine

benzo[b]thiophen-2-yl-2-boronic acid

K3PO4

→

5-(benzo[b]thiophen-2-yl)-7-methyl-7H-pyrrolo[2,3-d]pyrimidin-4-amine

Lösungsmittel

DMF

Reaktionsbedingungen

Aufarbeitung

1. 1
   SonstigeReaction
2. 2
   Einengenwas concentrated in vacuo
3. 3
   Sonstigepurified by RP-HPLC (MeCN:H2O:0.1% TFA)

Vorschrift

A solution of 5-iodo-7-methyl-7H-pyrrolo[2,3-d]pyrimidin-4-amine (5 mg, 0.018 mmol), benzo[b]thiophen-2-yl-2-boronic acid (16 mg, 0.091 mmol), K3PO4 (19.3 mg, 0.091 mmol) and Pd(PPh3)4 (12.5 mg, 0.011 mmol) in DMF (3 mL) was heated to 60° C. under an argon atmosphere. Reaction was concentrated in vacuo and purified by RP-HPLC (MeCN:H2O:0.1% TFA). ESI-MS (M+H)+ m/z calcd 281.1, found 281.3.

Quelle