Reaktion #325049

Reaktionsgleichung

sodium hydrogen cyanamide

2-(4-cyclohexyl-phenoxymethyl)-2-methyl-oxirane

→

white solid

Ausbeute 75.7%

5-(4-Cyclohexyl-phenoxymethyl)-5-methyl-oxazolidin-2-ylideneamine

Ausbeute 75.7%

Lösungsmittel

Methanol

Reaktionsbedingungen

Aufarbeitung

1. 1
   Einengenconcentrated in vacuo
2. 2
   workup.DISSOLUTIONThe residue was dissolved in methylene chloride
3. 3
   Waschenwashed with water
4. 4
   TrocknenThe methylene chloride layer was dried over 4 A molecular sieves
5. 5
   Filtrationfiltered
6. 6
   Einengenconcentrated in vacuo

Vorschrift

Methanol (250 ml) and sodium hydrogen cyanamide (1.92 g, 30 mmol) were added to a flask containing 2-(4-cyclohexyl-phenoxymethyl)-2-methyl-oxirane (6.15 g, 25 mmol). The reaction mixture was stirred overnight at room temperature and then concentrated in vacuo. The residue was dissolved in methylene chloride and washed with water, then saturated potassium carbonate. The methylene chloride layer was dried over 4 A molecular sieves, filtered and concentrated in vacuo to yield 5.46 g of a white solid. The white solid was recrystallized from ether to yield 1.11 g of the title compound as white crystals. A second crop yielded 0.64 g of white crystals.

Quelle