Reaktion #325009

Reaktionsgleichung

Ethyl iodide

3-oxo-pentanoic acid ethyl ester

NaOEt

→

title compound

Ausbeute 70.6%

2-Ethyl-3-oxo-pentanoic acid ethyl ester

Ausbeute 70.6%

Lösungsmittel

EtOH

Reaktionsbedingungen

Aufarbeitung

1. 1
   Sonstigehe reaction mixture
2. 2
   EinengenThe reaction mixture was concentrated
3. 3
   Wascheneluted with 1-2% EtOAc/heptane

Vorschrift

To a solution of 3-oxo-pentanoic acid ethyl ester (5.19 g, 36 mmol) in anhydrous EtOH (40 mL) was added NaOEt (21% wt. in EtOH, 11.7 mL, 36 mmol). he reaction mixture was heated to 80° C. Ethyl iodide (6.18 g, 39.6 mmol) was added dropwise at 80° C. Stirring was continued at 80° C. for 16 hours. The reaction mixture was concentrated and loaded onto a silica gel column and eluted with 1-2% EtOAc/heptane to give 4.38 g of the title compound.

Quelle