Reaktion #324545

Reaktionsgleichung

N-(3-chloroquinoxalin-2-yl)-3-nitrobenzenesulfonamide

3-methoxy-5-nitroaniline

p-xylene

→

N-(3-(3-methoxy-5-nitrophenylamino)quinoxalin-2-yl)-3-nitrobenzenesulfonamide

Ausbeute 42.0%

Lösungsmittel

DCM

Reaktionsbedingungen

Aufarbeitung

1. 1
   Temperaturto cool
2. 2
   Waschenwashed with 2M HCl and brine
3. 3
   Einengenconcentrated in vacuo
4. 4
   WaschenThe resulting solid was washed with Et2O

Vorschrift

N-(3-chloroquinoxalin-2-yl)-3-nitrobenzenesulfonamide (700 mg, 1.92 mmol), 3-methoxy-5-nitroaniline (645 mg, 3.84 mmol) and p-xylene (7 mL) were combined and heated to 140° C., then stirred for 16 hours at 130° C. The reaction was allowed to cool, placed in a sep. funnel, diluted with DCM, and washed with 2M HCl and brine and concentrated in vacuo. The resulting solid was washed with Et2O to give N-(3-(3-methoxy-5-nitrophenylamino)quinoxalin-2-yl)-3-nitrobenzenesulfonamide (400 mg, 42%). MS (EI) for C21H16N6O7S: 496.94 (MH+)

Quelle