Reaktion #324369

Reaktionsgleichung

N-[3-(dimethylamino)propyl]methacrylamide

butanesultone

acetone

methanol

→

4-sulfonatobutyl[3-(methacryloylamino)propyl]dimethylammonium

Ausbeute 85.5%

Lösungsmittel

acetonitrile

Reaktionsbedingungen

Aufarbeitung

1. 1
   Temperaturto cooling, to the reaction mixture
2. 2
   FiltrationThe crystals deposited were collected by filtration
3. 3
   Waschenthoroughly washed with acetone

Vorschrift

In 380 ml of acetonitrile were dissolved 130 g (0.764 mol) of N-[3-(dimethylamino)propyl]methacrylamide, 104 g of butanesultone and 234 mg of 4-hydroxy-2,2,6,6-tetramethylpiperidinoxy and the solution was heated at 70° C. for 6 hours. After allowing to cooling, to the reaction mixture were added 1,350 ml of acetone and 150 ml of methanol and the mixture was stirred at room temperature for one hour. The crystals deposited were collected by filtration and thoroughly washed with acetone to obtain 200.0 g (yield: 85%) of 4-sulfonatobutyl[3-(methacryloylamino)propyl]dimethylammonium.

Quelle