Reaktion #324240

ord-2d33e5c7285146a1a0b63e61f080f043

Reaktionsgleichung

Cc1cccc(Cc2cnc(NCCSCc3nc[nH]c3C)[nH]c2=O)c1.Cl.Cl
2-[2-(5-methyl-4-imidazolylmethylthio)ethylamino]-5-(3-methylbenzyl)-4-pyrimidone dihydrochloride
Cc1cccc(Cc2c[nH]c(=S)[nH]c2=O)c1
5-(3-methylbenzyl)-2-thiouracil
→
Cc1ccc(Cc2cnc(NCCSCc3nc[nH]c3C)[nH]c2=O)cc1.Cl.Cl
2-[2-(5-Methyl-4-imidazolylmethylthio)ethylamino]-5-(4-methylbenzyl)-4-pyrimidone dihydrochloride

Edukte

Cc1cccc(Cc2cnc(NCCSCc3nc[nH]c3C)[nH]c2=O)c1.Cl.Cl
2-[2-(5-methyl-4-imidazolylmethylthio)ethylamino]-5-(3-methylbenzyl)-4-pyrimidone dihydrochloride
Cc1cccc(Cc2c[nH]c(=S)[nH]c2=O)c1
5-(3-methylbenzyl)-2-thiouracil

Reagenzien

Keine

Reaktionsbedingungen

Detaillierte Bedingungen
See reaction.notes.procedure_details.

Vorschrift

In a similar manner 2-[2-(5-methyl-4-imidazolylmethylthio)ethylamino]-5-(3-methylbenzyl)-4-pyrimidone dihydrochloride m.p. 203.5°-205° (ex ethanol) may be prepared from 5-(3-methylbenzyl)-2-thiouracil.

Quelle

DOI: 10.6084/m9.figshare.5104873.v1Patent: US04159329uspto-grants-1979_06