Reaktion #324165

ord-663b0618c75145368eab0ce7fa61ecd4

Reaktionsgleichung

$C=C1CC[C@H](O)C/C1=C/C=C1\CCC[C@]2(C)[C@@H]([C@H](C)CCCC(C)C)CC[C@@H]12$

Vitamin D3

iodine

→

$C=C1CC[C@H](O)C/C1=C\C=C1/CCC[C@@]2(C)C1CC[C@@H]2[C@H](C)CCCC(C)C$

trans-vitamin D3

Ausbeute 61.3%

Edukte

$C=C1CC[C@H](O)C/C1=C/C=C1\CCC[C@]2(C)[C@@H]([C@H](C)CCCC(C)C)CC[C@@H]12$

Vitamin D3

iodine

Reagenzien

Keine

Lösungsmittel

hexane

Reaktionsbedingungen

Detaillierte Bedingungen

See reaction.notes.procedure_details.

Aufarbeitung

1
Waschenat 20° the solution was washed with aqueous sodium thiosulphate, water
2
Trocknendried over sodium sulphate
3
SonstigeAfter removal of the solvent, chromatography

Vorschrift

To a solution of Vitamin D3 (750 mgs) in hexane (20 ml) was added iodine (2 mgs). After stirring for 1 hr. at 20° the solution was washed with aqueous sodium thiosulphate, water and dried over sodium sulphate. After removal of the solvent, chromatography afforded trans-vitamin D3 (460mgs).

Quelle

DOI: 10.6084/m9.figshare.5104873.v1Patent: US04159326uspto-grants-1979_06