Reaktion #323194

ord-cced221111dc4956830f74cca61be129

Reaktionsgleichung

Cl.NC1=NCCN1Cc1ccc(Cl)cc1
product
Cl.NC1=NCCN1Cc1ccc(Cl)cc1
1-[(4-Chlorophenyl)Methyl]-4,5-Dihydro-1H-Imidazol-2-Amine Hydrochloride
Cl.NC1=NCCN1Cc1ccc(Cl)cc1
product
Cl.NC1=NCCN1Cc1ccc(Cl)cc1
1-[(4-Chlorophenyl)Methyl]-4,5-Dihydro-1H-Imidazol-2-Amine Hydrochloride
CCOC(=O)C(C#N)=NO
ethyl oximinocyanoacetate
→
Nc1nc2n(c(=O)c1N=O)CCN2Cc1ccc(Cl)cc1
7-Amino-1-[(4-Chlorophenyl)Methyl]-2,3-Dihydro-6-Nitrosoimidazo-[1,2-a]Pyrimidin-5-(1H)-One

Edukte

Cl.NC1=NCCN1Cc1ccc(Cl)cc1
product
Cl.NC1=NCCN1Cc1ccc(Cl)cc1
1-[(4-Chlorophenyl)Methyl]-4,5-Dihydro-1H-Imidazol-2-Amine Hydrochloride
Cl.NC1=NCCN1Cc1ccc(Cl)cc1
product
Cl.NC1=NCCN1Cc1ccc(Cl)cc1
1-[(4-Chlorophenyl)Methyl]-4,5-Dihydro-1H-Imidazol-2-Amine Hydrochloride
CCOC(=O)C(C#N)=NO
ethyl oximinocyanoacetate
—
crude product

Reagenzien

Keine

Reaktionsbedingungen

Detaillierte Bedingungen
See reaction.notes.procedure_details.

Aufarbeitung

  1. 1
    Sonstigerecrystallized from dimethylformamide, m.p. 290°-291°

Vorschrift

The product of Procedure 91 was condensed with ethyl oximinocyanoacetate according to the method described in Procedure 1. The crude product, 1.6 g., from 2.9 g. of the product of Procedure 91, was a blue solid, m.p. 273°-275° d, recrystallized from dimethylformamide, m.p. 290°-291° d.

Quelle

DOI: 10.6084/m9.figshare.5104873.v1Patent: US04642345uspto-grants-1987_02