Reaktion #323178

Reaktionsgleichung

product

7-Amino-8-[(4-Chlorophenyl)Methyl]-6-(Formylamino)-2,3-Dihydroimidazo[1,2-a]Pyrimidin-5(8H)-One

propionic anhydride

→

4-[(4-Chlorophenyl)Methyl]-2-Ethyl-6,7-Dihydroimidazo[1,2-a]Purin-9(4H)-One

Lösungsmittel

pyridine

Reaktionsbedingungen

Aufarbeitung

1. 1
   workup.ADDITIONA mixture of 25.00 g
2. 2
   Temperaturat reflux for 3 hr
3. 3
   TemperaturUpon cooling
4. 4
   Sonstigea white solid precipitated
5. 5
   workup.ADDITIONCH3CN was added
6. 6
   Filtrationthe white solid filtered
7. 7
   Sonstigeair-dried
8. 8
   Sonstigeto give crystals, mp 278.0°-279.0° (corr.)
9. 9
   SonstigeThe material may be recrystallized from DMF-i-PrOH

Vorschrift

A mixture of 25.00 g. (0.078 mol) of the product of Procedure 2 and 50 ml. dry pyridine in 50 ml. (0.388 mol) of propionic anhydride was heated at reflux for 3 hr. Upon cooling, a white solid precipitated. CH3CN was added, and the white solid filtered and air-dried to give crystals, mp 278.0°-279.0° (corr.). The material may be recrystallized from DMF-i-PrOH.

Quelle