Reaktion #322819

Reaktionsgleichung

2-amino-5-methoxythiophenol

methyl 2,4-dibromobutyrate

→

2-(2-bromoethyl)-7-methoxy-2H-1,4-benzothiazin-3(4H)-one

Ausbeute 65.3%

Lösungsmittel

dimethylformamide

Reaktionsbedingungen

Aufarbeitung

1. 1
   Filtrationthe resulting crystals were collected by filtration
2. 2
   Waschenwashed with water
3. 3
   SonstigeRecrystallization from methanol

Vorschrift

A solution of 3.10 g of 2-amino-5-methoxythiophenol and 5.20 g of methyl 2,4-dibromobutyrate in 30 ml of dimethylformamide was stirred at room temperature for 2 hours. The mixture was poured into ice-water and the resulting crystals were collected by filtration and washed with water. Recrystallization from methanol gave 3.94 g (65.2%) of 2-(2-bromoethyl)-7-methoxy-2H-1,4-benzothiazin-3(4H)-one as prisms, m.p. 142°-143° C.

Quelle