Reaktion #322544

Reaktionsgleichung

H2O

3-(4-methyl-1-piperazinyl)-1-phenylsulfonyl-1H-indazole

K2CO3

cyanogen bromide

→

4-[1 -(Phenylsulfonyl)-1H-indazol-3-yl]-1-piperazinecarbonitrile

Lösungsmittel

dimethylsulfoxide

DMSO

Reaktionsbedingungen

Aufarbeitung

1. 1
   SonstigeThe solid, which precipitated from solution
2. 2
   Filtrationwas collected by filtration
3. 3
   Waschenwas washed well with H2O affording 168 g (68%) of product
4. 4
   SonstigeA 5.2 g sample was recrystallized twice from ethanol-H2O yielding 4.0 g of 4-[1-(phenylsulfonyl)-1H-indazol-3-yl]-1-piperazinecarbonitrile, m.p.=178°-180° C.

Vorschrift

To a stirred mixture of 3-(4-methyl-1-piperazinyl)-1-phenylsulfonyl-1H-indazole (237 g, 0.67 mole), K2CO3 (102 g, 0.74 mole) and dimethylsulfoxide (DMSO, 2000 ml), under nitrogen, was added cyanogen bromide (72 g, 0.68 mmol) dissolved in DMSO (525 ml). The reaction was stirred at ambient temperature for 5.5 hours and was then poured into H2O (71). The solid, which precipitated from solution, was collected by filtration and was washed well with H2O affording 168 g (68%) of product. A 5.2 g sample was recrystallized twice from ethanol-H2O yielding 4.0 g of 4-[1-(phenylsulfonyl)-1H-indazol-3-yl]-1-piperazinecarbonitrile, m.p.=178°-180° C.

Quelle