Reaktion #3223

Reaktionsgleichung

methyl 2-(tert-butoxycarbonylamino)-4,6-dichloro-5-methoxybenzoate

trifluoroacetic acid

→

title compound

Ausbeute 87.0%

Methyl 2-amino-4,6-dichloro-5-methoxybenzoate

Ausbeute 87.0%

Lösungsmittel

methylene chloride

Reaktionsbedingungen

Aufarbeitung

1. 1
   WaschenThe reaction mixture was then washed with saturated aqueous sodium bicarbonate, drie (MgSO4)
2. 2
   Filtrationfiltered
3. 3
   Einengenconcentrated

Vorschrift

A solution o#methyl 2-(tert-butoxycarbonylamino)-4,6-dichloro-5-methoxybenzoate (2.3 g, 6.6 mM) and trifluoroacetic acid (6.0 g, 53 mM) in methylene chloride (23 mL) was stirred at room temperature for 1.5 hr. The reaction mixture was then washed with saturated aqueous sodium bicarbonate, drie (MgSO4), filtered and concentrated to obtain (87%) the title compound as a yellow oil; MS(CI): 250 (M+H).

Quelle