Reaktion #322185

Reaktionsgleichung

2-amino-5-(2,4-dichlorophenyl)-4,6-dichloropyrimidine

2-Amino-5-(2,4-dichlorophenyl)-4,6-dichloropyrimidine

ammonia

→

2,4-Diamino-6-chloro-5-(2,4-dichlorophenyl)-pyrimidine

Ausbeute 25.0%

title compound

Ausbeute 25.0%

Lösungsmittel

EtOH

Reaktionsbedingungen

Aufarbeitung

1. 1
   SonstigeThe cooled reaction mixture
2. 2
   Filtrationwas filtered
3. 3
   Sonstigeevaporated
4. 4
   Sonstigethe residue purified by flash column chromatography

Vorschrift

A mixture of 2-amino-5-(2,4-dichlorophenyl)-4,6-dichloropyrimidine (0.5 g) (Example 32) EtOH saturated with ammonia (20 ml) and copper powder (0.05 g) was heated in an autoclave at 180° C. for 18 hours. The cooled reaction mixture was filtered, evaporated and the residue purified by flash column chromatography to give the title compound (0.12, 25%), mp. 219° C. Microanalysis: Calcd: C, 40.82; H, 2.55; N, 19.05; Found: C, 41.27; H, 2.46; N, 18.74.

Quelle