Reaktion #322136

ord-9df99fe7b8e94422ba7c9f97a23f28c8

Reaktionsgleichung

Nc1nc(N)c(-c2ccc(Cl)cc2Cl)c(CBr)n1
2,4-diamino-5-(2,4-dichlorophenyl)-6-bromomethyl-pyrimidine
[C-]#N.[Na+]
sodium cyanide
→
N#CCc1nc(N)nc(N)c1-c1ccc(Cl)cc1Cl
2,4-Diamino-5-(2,4-dichlorophenyl)-6-cyanomethyl-pyrimidine

Edukte

Nc1nc(N)c(-c2ccc(Cl)cc2Cl)c(CBr)n1
2,4-diamino-5-(2,4-dichlorophenyl)-6-bromomethyl-pyrimidine
[C-]#N.[Na+]
sodium cyanide

Reagenzien

Keine

Lösungsmittel

CN(C)C=O
DMF

Reaktionsbedingungen

Detaillierte Bedingungen
See reaction.notes.procedure_details.

Vorschrift

This compound was prepared from 2,4-diamino-5-(2,4-dichlorophenyl)-6-bromomethyl-pyrimidine (Example 53) by reaction with sodium cyanide in DMF at room temperature, mp. 249°-251° C.

Quelle

DOI: 10.6084/m9.figshare.5104873.v1Patent: US05597827uspto-grants-1997_01