Reaktion #322022

Reaktionsgleichung

2-(carboxymethoxy)-5-[(2-chloro -α,α,α-trifluoro-p-tolyl)oxy]benzoic acid

ammonium hydroxide

ether

→

title product

Ausbeute 72.0%

2-(Carboxymethoxy)-5-[(2-chloro-α,α,α-trifluoro-p-tolyl)oxy]benzoic acid, diammonium salt

Ausbeute 72.0%

Lösungsmittel

water

methanol

Reaktionsbedingungen

Aufarbeitung

1. 1
   Einengenconcentrated in vacuo
2. 2
   Sonstigeto obtain a residue
3. 3
   TemperaturThe solution is cooled in an ice bath
4. 4
   Filtrationthe solid is collected by filtration

Vorschrift

A mixture of 2-(carboxymethoxy)-5-[(2-chloro -α,α,α-trifluoro-p-tolyl)oxy]benzoic acid (2.0 g, 5.12 mmol) and concentrated ammonium hydroxide solution (0.5 mL, 7.25 mmol) in water is stirred until homogeneous and concentrated in vacuo to obtain a residue. A solution of the residue in methanol is brought to the cloud point with ether. The solution is cooled in an ice bath and the solid is collected by filtration to give the title product as a white solid (1.5 g, 72%, mp 226-227).

Quelle