Reaktion #321871

Reaktionsgleichung

N-(2-chloroethyl)-7-chloro-4-quinolinamine hydrochloride

water

sodium hydroxide

→

colourless crystals

Ausbeute 64.3%

(RS)-(7-Chloro-quinolin-4-yl)-[2-(3-methyl-piperidin-1-yl)-ethyl]-amine

Ausbeute 64.3%

Lösungsmittel

3-methylpiperidine

Reaktionsbedingungen

Aufarbeitung

1. 1
   Extraktionextracted three times with 50 ml of ethyl acetate each time
2. 2
   WaschenThe combined extracts were washed with a small amount of water
3. 3
   Einengenconcentrated
4. 4
   SonstigeThe residue was recrystallized from 80 ml of acetone

Vorschrift

2.5 g of N-(2-chloroethyl)-7-chloro-4-quinolinamine hydrochloride in 25 ml of 3-methylpiperidine were held at 100° C. in a sealed tube for 24 hours. Thereafter, 100 ml of water were added, the mixture is adjusted to pH 12 by means of concentrated sodium hydroxide solution and extracted three times with 50 ml of ethyl acetate each time. The combined extracts were washed with a small amount of water and concentrated. The residue was recrystallized from 80 ml of acetone. 0.88 g of colourless crystals, m.p.: 148°-151° C., was obtained.

Quelle