Reaktion #3215

Reaktionsgleichung

6-iodo-1H-indole-2,3-dione

water

→

title compound

Ausbeute 81.8%

7-Iodo-2H-3,1-benzoxazine-2,4(1H)-dione

Ausbeute 81.8%

Lösungsmittel

acetic acid

acetic anhydride

Reaktionsbedingungen

Aufarbeitung

1. 1
   Temperaturwhile maintaining the temperature of the reaction mixture at 80°-90° C
2. 2
   Temperaturcooled
3. 3
   FiltrationThe resulting mixture was filtered
4. 4
   Sonstigethe collected solids dried

Vorschrift

To a stirred warm (80° C.) solution of 6-iodo-1H-indole-2,3-dione (3.0 g, 11 mM) in acetic acid (10 mL) and acetic anhydride (10 mL) was added in small portions chromium trioxide (1.83 g, 18.3 mM) while maintaining the temperature of the reaction mixture at 80°-90° C. The reaction mixture was then heated at 80° C. for 10 min, cooled and poured into water. The resulting mixture was filtered and the collected solids dried to provide the title compound as a yellow solid (2.6 g, 81.8%); MS(CI): 290 (M+H).

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