Reaktion #321479

Reaktionsgleichung

5-amino-4-bromo-3-methylisoxazole

5-chloro-3-methylbenzo[b]thiophene-2-sulphonyl chloride

→

N-(4-bromo-3-methyl-5-isoxazolyl)-5-chloro-3-methylbenzo[b]thiophene-2-sulfonamide

Ausbeute 18.0%

Reaktionsbedingungen

Aufarbeitung

1. 1
   SonstigePurification
2. 2
   Sonstigewas achieved by recrystallization from ethyl acetate/hexanes
3. 3
   Sonstigeto give a crystalline solid, m.p. 153°-155° C.

Vorschrift

N-(4-bromo-3-methyl-5-isoxazolyl)-5-chloro-3-methylbenzo[b]thiophene-2-sulfonamide was prepared in the same manner as described in Example 2 from 5-amino-4-bromo-3-methylisoxazole and 5-chloro-3-methylbenzo[b]thiophene-2-sulphonyl chloride in 18% yield. Purification was achieved by recrystallization from ethyl acetate/hexanes to give a crystalline solid, m.p. 153°-155° C.

Quelle