Reaktion #321284

ord-f91c47a9b0684e798e7acdf1e2968885

Reaktionsgleichung

Nc1cc[nH]c(=O)n1
cytosine
C[Si](C)(C)N[Si](C)(C)C
hexamethyldisilazane
O=S(=O)([O-])[O-].[NH4+].[NH4+]
ammonium sulfate
→
C[Si](C)(C)N(c1cc[nH]c(=O)n1)[Si](C)(C)C
bis-trimethylsilylcytosine

Edukte

Nc1cc[nH]c(=O)n1
cytosine
C[Si](C)(C)N[Si](C)(C)C
hexamethyldisilazane
O=S(=O)([O-])[O-].[NH4+].[NH4+]
ammonium sulfate

Reagenzien

Keine

Lösungsmittel

ClCCl
dichloromethane

Reaktionsbedingungen

Temperatur
27°CELSIUS
Detaillierte Bedingungen
See reaction.notes.procedure_details.

Aufarbeitung

  1. 1
    TemperaturThe mixture was heated to 115° C.-120° C. for 3 hours
  2. 2
    Sonstigethe excess hexamethyldisilazane was subsequently removed
  3. 3
    Sonstigea solid residue formed which

Vorschrift

To 5.78 g of cytosine were added 112 ml of hexamethyldisilazane and 50 mg of ammonium sulfate. The mixture was heated to 115° C.-120° C. for 3 hours with stirring and the excess hexamethyldisilazane was subsequently removed. This solution was then cooled to 27° C. and a solid residue formed which was reconstituted in 35 ml of dichloromethane to form a homogenous bis-trimethylsilylcytosine solution.

Quelle

DOI: 10.6084/m9.figshare.5104873.v1Patent: US05594124uspto-grants-1997_01