Reaktion #321281

ord-97c329d37bdf4705aa7b85b21e871282

Reaktionsgleichung

Nc1cc[nH]c(=O)n1
cytosine
C[Si](C)(C)N[Si](C)(C)C
hexamethyldisilazane
O=S(=O)([O-])[O-].[NH4+].[NH4+]
ammonium sulfate
→
C[Si](C)(C)N(c1cc[nH]c(=O)n1)[Si](C)(C)C
bis-trimethylsilylcytosine

Edukte

Nc1cc[nH]c(=O)n1
cytosine
C[Si](C)(C)N[Si](C)(C)C
hexamethyldisilazane
O=S(=O)([O-])[O-].[NH4+].[NH4+]
ammonium sulfate

Reagenzien

Keine

Reaktionsbedingungen

Temperatur
60°CELSIUS
Detaillierte Bedingungen
See reaction.notes.procedure_details.

Aufarbeitung

  1. 1
    TemperaturThe solution was heated to 115° C.-120° C. for 1 and 1/2 hours
  2. 2
    Sonstigethe excess hexamethyldisilazane subsequently removed

Vorschrift

To 5.78 g of cytosine were added 112 ml of hexamethyldisilazane and 100 mg of ammonium sulfate. The solution was heated to 115° C.-120° C. for 1 and 1/2 hours with stirring and the excess hexamethyldisilazane subsequently removed. The mixture was cooled to 60° C. and reconstituted in 40 ml of 1,2-dichloroethane to form a homogenous solution of bis-trimethylsilylcytosine.

Quelle

DOI: 10.6084/m9.figshare.5104873.v1Patent: US05594124uspto-grants-1997_01