Reaktion #321226

Reaktionsgleichung

THF hexane

acetone

2-{3-methyl-3-hydroxybutynyl}-5-{2-(4pyridyl)ethynyl}thiophene

KOH

→

2-Ethynyl-5-(4-pyridyl)ethynyl Thiophene

Ausbeute 69.9%

Lösungsmittel

methanol

toluene

Reaktionsbedingungen

Aufarbeitung

1. 1
   Sonstigeformed in the reaction
2. 2
   Sonstigethe methanol were collected in the receiving flask (total heating time, about 1.5 to 2 hours)
3. 3
   SonstigeThe toluene was removed under reduced pressure
4. 4
   Sonstigethe reddish residue was purified by chromatography on silica gel using 2:8 THF/petroleum ether as the eluting solvent
5. 5
   Sonstigeto obtain 4.65 g (69.92% yield) of light yellow solid
6. 6
   Sonstigeat 138° C.
7. 7
   Sonstigeat 144.67° C
8. 8
   Sonstigeup to about 400° C.

Vorschrift

A distillation apparatus was set up and 2-{3-methyl-3-hydroxybutynyl}-5-{2-(4pyridyl)ethynyl}thiophene (8.50 g, 31.84 mmol), KOH (1.78 g, 21.84 mmol) in 25 ml of methanol and 200 ml of toluene were added to the distillation flask. The flask was heated to about 90° C. until all the acetone formed in the reaction and the methanol were collected in the receiving flask (total heating time, about 1.5 to 2 hours). The toluene was removed under reduced pressure and the reddish residue was purified by chromatography on silica gel using 2:8 THF/petroleum ether as the eluting solvent to obtain 4.65 g (69.92% yield) of light yellow solid. TLC (3:7 THF/hexane): Rf =0.28, mp=134.5°-135.5° C. FTIR (cm-1): 3304 (H--C≡C), 2206 (C≡C). Elemental analysis: Calculated for C13H7NS (mw 209.26): C, 74.61; H, 3.37; N, 6.70. Found: C, 74.54; H, 3.19; N, 6.72. DSC thermogram of the monomer showed a melting transition at 138° C. and a transition for thermal curing of the terminal C≡C at 144.67° C. TGA thermogram showed about 10-20% weight loss at the terminal C≡C cure temperature (about 150° C.) after which there was little weight loss up to about 400° C.

Quelle