Reaktion #321038

Reaktionsgleichung

1,3-dibromopropane

3-acetamidophenol

potassium carbonate

→

3-(3-acetamidophenoxy)propyl bromide

Lösungsmittel

dichloromethane

Reaktionsbedingungen

Aufarbeitung

1. 1
   TemperaturThe resulting mixture was heated
2. 2
   Temperaturat reflux for 6 hours
3. 3
   Sonstigeovernight
4. 4
   Sonstigeat room temperature
5. 5
   FiltrationSolids were filtered from the reaction mixture
6. 6
   Einengenthe solution was concentrated to an oil, which
7. 7
   Sonstigewas purified

Vorschrift

To 3-acetamidophenol (15.1 g) in dichloromethane (500 ml, dry) was added potassium carbonate (20 g) and then 1,3-dibromopropane (30 g). The resulting mixture was heated at reflux for 6 hours and then overnight at room temperature. After an additional 24 hours, the reaction was complete. Solids were filtered from the reaction mixture, and the solution was concentrated to an oil, which was purified to yield 3-(3-acetamidophenoxy)propyl bromide, 13.2 g.

Quelle