Reaktion #320638

Reaktionsgleichung

6-bromopyrrolo[1,2-a]pyrazine

2-aminoethanethiol hydrochloride

potassium carbonate

→

title compound

Ausbeute 76.5%

6-(2-amino-ethylthio)-pyrrolo[1,2-a]pyrazine

Ausbeute 76.5%

Lösungsmittel

dimethylformamide

Reaktionsbedingungen

Aufarbeitung

1. 1
   TemperaturThe reaction mixture was refluxed for 5 hours
2. 2
   Extraktionextracted with ethyl acetate (50 ml×3)
3. 3
   SonstigeThe organic layer was isolated
4. 4
   Einengenconcentrated to dryness
5. 5
   Sonstigeand the residue was chromatographed over silica gel

Vorschrift

To the solution of 2.0 g of 6-bromopyrrolo[1,2-a]pyrazine prepared in Preparation Example 7 dissolved in 20 ml of dimethylformamide were added 1.8 g of 2-aminoethanethiol hydrochloride and 1.0 g of potassium carbonate. The reaction mixture was refluxed for 5 hours, poured into 100 ml of ice-water and then extracted with ethyl acetate (50 ml×3). The organic layer was isolated and concentrated to dryness; and the residue was chromatographed over silica gel to obtain 1.5 g of title compound.

Quelle