Reaktion #320633

Reaktionsgleichung

1-methylpyrrolo[1,2-a]pyrazine

N-bromosuccinimide

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title compound

Ausbeute 80.0%

6-bromo-1-methyl-pyrrolo[1,2-a]pyrazine

Ausbeute 80.0%

Lösungsmittel

chloroform

Reaktionsbedingungen

Aufarbeitung

1. 1
   Sonstigeat 0° C
2. 2
   Einengenand the resulting solution was concentrated
3. 3
   SonstigeThe residue was chromatographed over silica gel

Vorschrift

5.0 g of 1-methylpyrrolo[1,2-a]pyrazine prepared in Preparation Example 2 was dissolved in 60 ml of chloroform; and 6.7 g of N-bromosuccinimide was added thereto at 0° C. The reaction mixture was stirred for 30 minutes at the same temperature; and the resulting solution was concentrated. The residue was chromatographed over silica gel to obtain 6.3 g of title compound (yield: 80%).

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