Reaktion #320082

Reaktionsgleichung

4-bromophenol

NaOH

3-bromomethylheptane

→

4-(2-ethylhexyloxy)bromobenzene

Ausbeute 84.0%

Lösungsmittel

methylcellosolve

Reaktionsbedingungen

Aufarbeitung

1. 1
   Sonstigeequipped with stirrer, condenser
2. 2
   workup.ADDITIONare added dropwise over a period of 45 minutes
3. 3
   SonstigeSolvent and excess bromide are removed in vacuo
4. 4
   ExtraktionThe resulting solution is extracted three times with water
5. 5
   TrocknenThe organic phase is dried over sodium sulfate
6. 6
   Sonstigeevaporated to dryness

Vorschrift

A 1 l sulfonating flask equipped with stirrer, condenser, dropping funnel and internal thermometer is charged with 86.5 g (0.5 mol) of 4-bromophenol in 500 ml of methylcellosolve. After the mixture is heated to 60° C., 70.0 g of 30% NaOH (0.53 mol) are slowly run in. Stirring is continued for 15 minutes before 116.8 g (0.575 mol) of 3-bromomethylheptane are added dropwise over a period of 45 minutes. The reaction is continued overnight at 100° C. The thin-layer chromatogram shows almost quantitative conversion. Solvent and excess bromide are removed in vacuo, and the residue (oil) is taken up in 600 ml of toluene. The resulting solution is extracted three times with water. The organic phase is dried over sodium sulfate and evaporated to dryness to give 119.3 g (84% of theory) of 4-(2-ethylhexyloxy)bromobenzene as a light yellow oil.

Quelle