Reaktion #320059

ord-173c904036b3494ca7a6e3278b1b792f

Reaktionsgleichung

CCS
ethyl mercaptan
O=C([O-])[O-].[K+].[K+]
potassium carbonate
O=C1c2ccccc2COc2ccc(OCc3ccc4cc(F)c(Cl)cc4n3)cc21
2-(7-chloro-6-fluoroquinolin-2-yl)methoxy-11-oxo-6,11-dihydrodibenz[b,e]oxepine
→
CCSc1cc2ccc(COc3ccc4c(c3)C(=O)c3ccccc3CO4)nc2cc1Cl
2-(7-Chloro-6-ethylthioquinolin-2-yl)methoxy-11-oxo-6,11-dihydrodibenz[b,e]oxepine

Edukte

CCS
ethyl mercaptan
O=C([O-])[O-].[K+].[K+]
potassium carbonate
O=C1c2ccccc2COc2ccc(OCc3ccc4cc(F)c(Cl)cc4n3)cc21
2-(7-chloro-6-fluoroquinolin-2-yl)methoxy-11-oxo-6,11-dihydrodibenz[b,e]oxepine

Reagenzien

Keine

Lösungsmittel

CN(C)C=O
dimethylformamide

Reaktionsbedingungen

Temperatur
90°CELSIUS
Detaillierte Bedingungen
See reaction.notes.procedure_details.

Vorschrift

0.37 ml of ethyl mercaptan and 1.12 g of potassium carbonate were added to 2.0 g of 2-(7-chloro-6-fluoroquinolin-2-yl)methoxy-11-oxo-6,11-dihydrodibenz[b,e]oxepine dissolved in 80 ml of dimethylformamide and the mixture was stirred at 90° C. for 4 hours.

Quelle

DOI: 10.6084/m9.figshare.5104873.v1Patent: US05591752uspto-grants-1997_01