Reaktion #320048

Reaktionsgleichung

sodium boron hydride

7-chloro-6-fluoro-2-formylquinoline

→

title compound

Ausbeute 69.4%

7-Chloro-6-fluoro-2-hydroxymethylquinoline

Ausbeute 69.4%

Lösungsmittel

methanol

Reaktionsbedingungen

Aufarbeitung

1. 1
   Sonstigeobtained in Reference example 2
2. 2
   SonstigeAfter the solvent was removed
3. 3
   Extraktionthe residue was extracted with ice water-methylene chloride
4. 4
   Waschenthe organic layer was washed with water
5. 5
   Trocknendried over anhydrous sodium sulfate
6. 6
   SonstigeAfter the solvent was removed

Vorschrift

3 g of sodium boron hydride was added to 11.19 g of 7-chloro-6-fluoro-2-formylquinoline obtained in Reference example 2 suspended in 250 ml of methanol and the mixture was stirred at room temperature for 1 hour. After the solvent was removed, the residue was extracted with ice water-methylene chloride and the organic layer was washed with water and dried over anhydrous sodium sulfate. After the solvent was removed, the residue was applied to silica gel column chromatography to obtain 7.84 g of the title compound.

Quelle