Reaktion #319987

ord-fd3cc8786af443e4bf1b3720d652f9e3

Reaktionsgleichung

CC(=O)[C@H]1CC[C@H]2[C@@H]3CC[C@H]4C[C@H](OC(=O)c5cccnc5)CC[C@]4(C)[C@H]3CC[C@]12C
3α-nicotinoyloxy-5α-pregnan-20-one
CI
methyliodide
→
CC(=O)[C@H]1CC[C@H]2[C@@H]3CC[C@H]4C[C@H](OC(=O)C5=CC=CN(C)C5)CC[C@]4(C)[C@H]3CC[C@]12C.[I-]
crude product
CC(=O)[C@H]1CC[C@H]2[C@@H]3CC[C@H]4C[C@H](OC(=O)C5=CC=CN(C)C5)CC[C@]4(C)[C@H]3CC[C@]12C.[I-]
3α-N-methyl-nicotinoyloxy,5α-pregnan-20-one iodide

Edukte

CC(=O)[C@H]1CC[C@H]2[C@@H]3CC[C@H]4C[C@H](OC(=O)c5cccnc5)CC[C@]4(C)[C@H]3CC[C@]12C
3α-nicotinoyloxy-5α-pregnan-20-one
CI
methyliodide

Reagenzien

Keine

Lösungsmittel

CC(C)=O
acetone

Reaktionsbedingungen

Detaillierte Bedingungen
See reaction.notes.procedure_details.

Aufarbeitung

  1. 1
    Temperaturwas refluxed gently for 17 hours
  2. 2
    EinengenThe reaction mixture was concentrated in vacuo

Vorschrift

A mixture of 3α-nicotinoyloxy-5α-pregnan-20-one (770 mg, 421 g/m, 1.8 mmol) and methyliodide (3.0 mL, 141 g/m, -20 mmol) in 30 mL of acetone was refluxed gently for 17 hours. The reaction mixture was concentrated in vacuo to give the crude product.

Quelle

DOI: 10.6084/m9.figshare.5104873.v1Patent: US05591733uspto-grants-1997_01