Reaktion #319159

Reaktionsgleichung

hydrochloric acid

sulfonamide

2-[[5-(Methylthio)-1,3,4-thiadiazol-2-yl]methyl]benzenesulfonamide

phenyl(4-methoxy-6-methyl-1,3,5-triazin-2-yl)carbamate

DBU

→

subject compound

Ausbeute 32.2%

N-[(4-Methoxy-6-methyl-1,3,5-triazin-2-yl)aminocarbonyl]-2-[[5-(methylthio)-1,3,4-thiadiazol-2-yl]methyl]-benzenesulfonamide

Ausbeute 32.2%

Lösungsmittel

water

p-dioxane

Reaktionsbedingungen

Aufarbeitung

1. 1
   Filtrationfiltration
2. 2
   Waschenthe residue was washed with water (2×20ml)
3. 3
   Trocknenwith ether (1×20ml) and suction-dried

Vorschrift

By the procedure of Example 4, 0.3 g of the sulfonamide prepared in Example 3 was reacted with 0.29 g of phenyl(4-methoxy-6-methyl-1,3,5-triazin-2-yl)carbamate and 0.15 g of "DBU" in 10 ml of p-dioxane. After stirring two hours at room temperature the solution was diluted with about 75 ml of water and acidified with concentrated hydrochloric acid (red to litmus paper). Following filtration, the residue was washed with water (2×20ml) then with ether (1×20ml) and suction-dried to give 0.15 g of the subject compound; m.p. 140°-146° C. NMR (CDCl3): δ2.6(d,6H,SCH3, OCH3); 4.1 (S, 3H, CH3); 4.9(S, 2H, CH2); 7.4-7.7(m, 4H, Ar+NH); 8.3(d, 1H, Ar).

Quelle