Reaktion #318921

Reaktionsgleichung

methyl 4-(methylthio)-2-nitrobenzoate

hydrogen

→

methyl 2-amino-4-(methylthio)benzoate

Lösungsmittel

methyl acetate

Reaktionsbedingungen

Aufarbeitung

1. 1
   FiltrationThe mixture was filtered through Celite®

Vorschrift

A mixture of methyl 4-(methylthio)-2-nitrobenzoate (11.3 g, 49.7 mmol) and 5% platinum sulfide on carbon catalyst (0.7 g) in methyl acetate (40 mL) was hydrogenated at 750 psi and 75° C. until hydrogen uptake ceased. The mixture was filtered through Celite®, and the filtrate solvent was rotary evaporated, leaving methyl 2-amino-4-(methylthio)benzoate as a slightly tan crystalline solid (8.7 g melting at 57°-59° C.

Quelle