Reaktion #318377

Reaktionsgleichung

1,3-dithiane

water

3,4,5-trimethoxybenzyl chloride

→

2-(3,4,5-trimethoxyphenylmethyl)-1,3-dithiane

Lösungsmittel

tetrahydrofuran

pentane

tetrahydrofuran

Reaktionsbedingungen

Aufarbeitung

1. 1
   workup.ADDITIONwas added over a period of 15 minutes
2. 2
   Temperaturafter which time it was warmed to 0° C
3. 3
   Sonstigethe tetrahydrofuran was removed by evaporation at a temperature below 40° C
4. 4
   ExtraktionThe resultant white slurry was then extracted with a mixture of methylene chloride and water
5. 5
   SonstigeThe organic layer was then evaporated
6. 6
   Waschenthe crude product was washed with petroleum ether
7. 7
   Sonstigeto yield a white solid

Vorschrift

To a solution of 26.7 g of 1,3-dithiane in 222 ml of tetrahydrofuran which has been cooled to -78° C. was added over a period of 15 minutes, 137 ml of 1.7M solution of tetra-butyl lithium in pentane. The resultant mixture was then stirred for 45 minutes, while maintaining the temperature at -78° C., after which time it was warmed to 0° C. The mixture was then added to an ice-cold solution of 48.0 g of 3,4,5-trimethoxybenzyl chloride in 222 ml of tetrahydrofuran over a period of 20 minutes, after which time it was stirred for an additional 90 minutes at 0° C. 50 ml of water was then carefully added and the tetrahydrofuran was removed by evaporation at a temperature below 40° C. The resultant white slurry was then extracted with a mixture of methylene chloride and water. The organic layer was then evaporated and the crude product was washed with petroleum ether to yield a white solid.

Quelle