Reaktion #3172

Reaktionsgleichung

3(3,4,5-trifluorophenyl)thiophene

1-bromo-2,4-difluorobenzene

1-bromo-3,4,5-trifluorobenzene

→

pure product

Ausbeute 97.0%

3(2,4-difluorophenyl)thiophene

Ausbeute 97.0%

Reaktionsbedingungen

Aufarbeitung

1. 1
   Sonstigethe coupling reaction mixture
2. 2
   Temperaturwas heated
3. 3
   Temperaturto reflux in an oil bath for 10 hours
4. 4
   Temperaturto being heated in an oil bath for 0.5 hour
5. 5
   workup.STIRRINGwith periodically stirring)
6. 6
   SonstigeNo further purification
7. 7
   Sonstigeby recrystallization

Vorschrift

The same procedures set forth above in Example (1)(a) for synthesizing 3(3,4,5-trifluorophenyl)thiophene were followed, with the exception that 1-bromo-2,4-difluorobenzene was substituted for 1-bromo-3,4,5-trifluorobenzene as the 1-bromo-substituted fluorobenzene, and the coupling reaction mixture was heated to reflux in an oil bath for 10 hours with stirring at 80° C. (as opposed to being heated in an oil bath for 0.5 hour with periodically stirring). No further purification by recrystallization was required to obtain a 97 to 98% pure product.

Quelle