Reaktion #316723

Reaktionsgleichung

(3R,4R)-3-(tert-butoxycarbonylamino)-4-fluoromethyl-3-methyl-1-[(1R)-1-phenylethyl]pyrrolidine

→

(3R,4R)-3-(tert-Butoxycarbonylamino)-4-fluoromethyl-3-methylpyrrolidine

Lösungsmittel

hydrogen

ethanol

Reaktionsbedingungen

Aufarbeitung

1. 1
   SonstigeAfter removing the catalyst
2. 2
   Filtrationby filtration
3. 3
   Einengenthe filtrate was concentrated under reduced pressure
4. 4
   Sonstigeto obtain 169 mg (98%) of the crude target compound as a colorless transparent syrup substance

Vorschrift

To a solution of (3R,4R)-3-(tert-butoxycarbonylamino)-4-fluoromethyl-3-methyl-1-[(1R)-1-phenylethyl]pyrrolidine (250 mg, 0.743 mmol) in ethanol (10 mL) was added 10% palladium-carbon catalyst (containing 52.8% water, 250 mg), and the suspension was stirred in an oil bath at 40° C. for 1.5 hours in hydrogen gas atmosphere. After removing the catalyst by filtration, the filtrate was concentrated under reduced pressure to obtain 169 mg (98%) of the crude target compound as a colorless transparent syrup substance.

Quelle