Reaktion #316708

Reaktionsgleichung

benzyloxycarbonyl chloride

sodium hydrogencarbonate

tert-butyl(3S)-4-hydroxy-3-methyl-1-[(1R)-1-phenylethyl]pyrrolidine-3-carboxylate

hydrochloric acid

→

title compound

Ausbeute 90.4%

tert-Butyl(3S)-1-benzyloxycarbonyl-4-hydroxy-3-methylpyrrolidine-3-carboxylate

Ausbeute 90.4%

Lösungsmittel

water

tetrahydrofuran

hydrogen

ethanol

Reaktionsbedingungen

Aufarbeitung

1. 1
   FiltrationAfter filtering the reaction mixture
2. 2
   workup.ADDITIONwas further added in an ice bath
3. 3
   workup.STIRRINGThe reaction mixture was stirred at room temperature for 2 hours
4. 4
   Extraktionextracted with ethyl acetate (100 mL ×2)
5. 5
   WaschenThe resulting organic layer was washed with saturated aqueous solution of sodium chloride (20 mL)
6. 6
   Trocknendried with anhydrous sodium sulfate
7. 7
   FiltrationAfter the filtration
8. 8
   Einengenthe filtrate was concentrated under reduced pressure
9. 9
   Sonstigethe residue was purified by silica gel column chromatography (hexane:ethyl acetate, 2:1→1:2)

Vorschrift

To a solution of tert-butyl(3S)-4-hydroxy-3-methyl-1-[(1R)-1-phenylethyl]pyrrolidine-3-carboxylate (1.49 g, 4.88 mmol) in ethanol (30 mL), 1N hydrochloric acid (5.12 mL, 5.12 mmol) was added at room temperature, and the mixture was stirred at 10 minutes. 10% palladium-carbon catalyst (1.40 g) was added to the reaction mixture, and the suspension was stirred in an oil bath at 40° C. for 2 hours in hydrogen atmosphere at normal pressure. After filtering the reaction mixture and concentrating the filtrate, tetrahydrofuran (20 mL), water (20 mL), and sodium hydrogencarbonate (2.05 g, 24.4 mmol) were added to the residue, and benzyloxycarbonyl chloride (836 μl, 5.86 mmol) was further added in an ice bath. The reaction mixture was stirred at room temperature for 2 hours, and extracted with ethyl acetate (100 mL ×2). The resulting organic layer was washed with saturated aqueous solution of sodium chloride (20 mL), and dried with anhydrous sodium sulfate. After the filtration, the filtrate was concentrated under reduced pressure, and the residue was purified by silica gel column chromatography (hexane:ethyl acetate, 2:1→1:2) to obtain 1.48 g (90%) of the title compound as a colorless oily substance.

Quelle