Reaktion #316217

Reaktionsgleichung

hydrochloric acid

2-Amino-pyridine-3-carbaldehyde

1-bromo-butan-2-one

sodium hydroxide

→

2-ethyl-[1,8]naphthyridin-3-ol

Ausbeute 74.0%

Reaktionsbedingungen

Aufarbeitung

1. 1
   Sonstigethe suspension was hermetically sealed and, in this state
2. 2
   Filtrationthe precipitate was then filtered
3. 3
   WaschenThe residue was washed with water and chloroform
4. 4
   SonstigeThe powder as the residue was dried under the reduced pressure

Vorschrift

2-Amino-pyridine-3-carbaldehyde (100 mg) and 1-bromo-butan-2-one (124 mg) were suspended in a 5 N aqueous sodium hydroxide solution (0.6 ml), and the suspension was hermetically sealed and, in this state, was allowed to stand for 3 days. The reaction solution was neutralized with 10% hydrochloric acid, and the precipitate was then filtered. The residue was washed with water and chloroform. The powder as the residue was dried under the reduced pressure to give 2-ethyl-[1,8]naphthyridin-3-ol (106 mg, yield 74%).

Quelle