Reaktion #316189

Reaktionsgleichung

3-[7-Hydroxy-6-methoxy-quinolin-4-yloxy]-2-methyl-[1,8]naphthyridine

Potassium carbonate

4-bromo-1-butanol

→

title compound

Ausbeute 35.0%

4-[6-Methoxy-4-(2-methyl-[1,8]naphthyridin-3-yloxy)-quinolin-7-yloxy]-butan-1-ol

Ausbeute 35.0%

Lösungsmittel

N,N-dimethylformamide

Reaktionsbedingungen

Aufarbeitung

1. 1
   Sonstigeto prepare a solution
2. 2
   SonstigeThe solvent was removed by distillation under the reduced pressure
3. 3
   workup.ADDITIONWater was then added to the residue
4. 4
   Extraktionthe mixture was extracted with chloroform
5. 5
   WaschenThe chloroform layer was washed with saturated brine
6. 6
   Trocknenwas dried over anhydrous sodium sulfate
7. 7
   SonstigeThe solvent was removed by distillation under the reduced pressure
8. 8
   Sonstigethe residue was purified by thin layer chromatography

Vorschrift

3-[7-Hydroxy-6-methoxy-quinolin-4-yloxy]-2-methyl-[1,8]naphthyridine (45 mg) was dissolved in N,N-dimethylformamide (2 ml) to prepare a solution. Potassium carbonate (56 mg) and 4-bromo-1-butanol (62 mg) were added to the solution, and the mixture was stirred at room temperature overnight. The solvent was removed by distillation under the reduced pressure. Water was then added to the residue, and the mixture was extracted with chloroform. The chloroform layer was washed with saturated brine and was dried over anhydrous sodium sulfate. The solvent was removed by distillation under the reduced pressure, and the residue was purified by thin layer chromatography using chloroform-acetone to give the title compound (19 mg, yield 35%).

Quelle