Reaktion #316039

Reaktionsgleichung

hydrochloric acid

Sodium hydroxide

water

5-Fluoro-1H-indole-2,3-dione

2-hydroxy-1-phenyl-ethanone

→

6-fluoro-3-hydroxy-2-phenyl-quinoline-4-carboxylic acid

Ausbeute 21.0%

Lösungsmittel

methanol

Reaktionsbedingungen

Aufarbeitung

1. 1
   Sonstigeto prepare a solution
2. 2
   Waschenthe precipitated crystal was washed with methanol and water

Vorschrift

5-Fluoro-1H-indole-2,3-dione (1.19 g) and 2-hydroxy-1-phenyl-ethanone (2.25 g) were dissolved in methanol (70 ml) to prepare a solution. Sodium hydroxide (4.82 g) and water (30 ml) were added to the solution, and the mixture was stirred at room temperature overnight. Dilute hydrochloric acid was added to the reaction solution, and the precipitated crystal was washed with methanol and water to give 6-fluoro-3-hydroxy-2-phenyl-quinoline-4-carboxylic acid (427 mg, yield 21%).

Quelle