Reaktion #315467

Reaktionsgleichung

5-fluoropyridine-2-carboxamide

4-[1,3]dioxolan-2-yl-2-methylphenol

→

title compound

Ausbeute 35.5%

5-(4-Formyl-2-methylphenoxy)pyridine-2-carboxamide

Ausbeute 35.5%

Reaktionsbedingungen

Vorschrift

Using a method similar to Example 388 Part D, using 5-fluoropyridine-2-carboxamide (Example 388 Part C) (0.400 g, 2.85 mmol) and 4-[1,3]dioxolan-2-yl-2-methylphenol (Example 388, Part C2) (0.514 g, 2.85 mmol) gives the title compound (0.259 g): TLC [silica gel 60 F254, 30% ethyl acetate in dichloromethane] Rf=0.20; HPLC [YMC-Pack Pro C-18 (150×4.6 mm, S-5 microm), 0.1% TFA/acetonitrile in 0.1% TFA/water at 1.0 mL/min, 5-95% over 19 min], tR=12.1 min, 73.1% purity.

Quelle