Reaktion #315465

Reaktionsgleichung

4-[1,3]dioxolan-2-ylphenol

NaH

5-fluoropyridine-2-carboxamide

→

5-(4-[1,3]dioxolan-2-ylphenoxy)pyridine-2-carboxamide

Lösungsmittel

DMF

Reaktionsbedingungen

Aufarbeitung

1. 1
   TemperaturHeat at 80° C. for 4.5 hours
2. 2
   Einengenbefore concentrating to dryness

Vorschrift

Dissolve 4-[1,3]dioxolan-2-ylphenol (Part C2, 0.471 g, 2.85 mmol) in DMF (89.5 mL). Add NaH (80% in mineral oil) (0.128 g, 4.28 mmol). Stir at room temperature for about an hour before adding 5-fluoropyridine-2-carboxamide (0.400 g, 2.85 mmol). Heat at 80° C. for 4.5 hours before concentrating to dryness to form 5-(4-[1,3]dioxolan-2-ylphenoxy)pyridine-2-carboxamide.

Quelle