Reaktion #314872

Reaktionsgleichung

Methyl isobutyrylacetate

5-aminoindazole

→

title compound

N-1H-indazol-5-yl-4-methyl-3-oxopentanamide

Reaktionsbedingungen

Aufarbeitung

1. 1
   SonstigeThe crude mixture was then purified by silica gel chromatography

Vorschrift

Methyl isobutyrylacetate (3 mL) was mixed with 5-aminoindazole (0.50 g) and heated In a SmithSynthesizer to 180° C. for 300 seconds. The crude mixture was then purified by silica gel chromatography to yield the title compound as a purple solid. 1H NMR (keto- tautomer) (400 MHz, DMSO-D6) δ ppm 12.98 (s, 1H), 10.06 (s, 1H), 8.11 (s, 1H), 8.02 (s, 1H), 7.48 (d, 1H), 7.38 (d, 1H), 3.62 (s, 2H), 2.78 (sept, 1H), 1.06 (d, 6H). MS m/z 246 (M+1)+.

Quelle