Reaktion #314736

Reaktionsgleichung

2-Amino-6-chlorobenzoic acid

ethyl chloroformate

acetyl chloride

→

5-chloroisatoic anhydride

Ausbeute 97.0%

Lösungsmittel

1,4-dioxane

Reaktionsbedingungen

Aufarbeitung

1. 1
   TemperaturThe mixture was heated
2. 2
   Temperaturat reflux for 1 hour
3. 3
   Filtrationafter which the precipitated product was filtered off
4. 4
   Waschenwashed with toluene
5. 5
   SonstigeDrying in vacuum

Vorschrift

2-Amino-6-chlorobenzoic acid (30 g) was suspended in 1,4-dioxane (225 ml) and ethyl chloroformate (75 ml) was added. The mixture was heated at reflux for 1 hour, then cooled to 50° C., and acetyl chloride (75 ml) was added. The mixture was stirred for 10 hours, after which the precipitated product was filtered off and washed with toluene. Drying in vacuum yields 5-chloroisatoic anhydride (33 g, 97% yield).

Quelle