Reaktion #314592

Reaktionsgleichung

5-benzyloxyindole

ethylmagnesium bromide

product

2,2,3,3-tetramethylcyclopropanecarbonyl chloride

→

title compound

Ausbeute 27.0%

(5-Benzyloxy-1H-indol-3-yl)-(2,2,3,3-tetramethyl-cyclopropyl)-methanone

Ausbeute 27.0%

Lösungsmittel

dichloromethane

Reaktionsbedingungen

Vorschrift

A mixture of 5-benzyloxyindole (1.2 g, 5.6 mmol), ethylmagnesium bromide (1.0 M solution in THF, 6.1 mL, 6.1 mmol), zinc chloride (1.0 M solution in Et2O, 6.1 mL, 6.1 mmol) and the product of Example 1A (5.6 mmol) in 25 mL of dichloromethane was processed as described in Example 1B to provide the title compound (0.53 g, 1.5 mmol, 27% yield). MS (DCI/NH3) m/z 348 (M+H)+.

Quelle