Reaktion #314292

Reaktionsgleichung

3-(3,4-dimethyl-benzoyl)-6-trifluoromethyl-1H-quinolin-4-one

sodium hydride

2-bromomethylpyridine hydrobromide

→

3-(3,4-Dimethyl-benzoyl)-1-pyridin-2-ylmethyl-6-trifluoromethyl-1H-quinolin-4-one

Lösungsmittel

N,N-dimethylformamide

Reaktionsbedingungen

Vorschrift

Experimental conditions analogous to those described for Step 3 of Example 1, from 55 mg (0.16 mmol) of 3-(3,4-dimethyl-benzoyl)-6-trifluoromethyl-1H-quinolin-4-one, 18 mg of 60% sodium hydride, 52 mg of 2-bromomethylpyridine hydrobromide and 1 mL of N,N-dimethylformamide. Yield: 49 mg of a white solid: LC-MSD, m/z for C25H19F2N2O2 [M+H]+=437.5; HPLC retention time: 2.6 min.

Quelle