Reaktion #3142
ord-4d14267579d347aaab5da8765031fa8d
Reaktionsgleichung
4,6-dihydroxy-2-methylpyrimidinamine
sodium ethoxide
sodium
Acetamidine hydrochloride
diethyl malonate
→
4,6-dihydroxy-2-methylpyrimidine
Edukte
Reagenzien
Keine
Lösungsmittel
Reaktionsbedingungen
Detaillierte Bedingungen
See reaction.notes.procedure_details.
Aufarbeitung
- 1Temperaturthe reaction mixture heated
Vorschrift
The first intermediate, 4,6-dihydroxy-2-methylpyrimidinamine, is synthesized by preparing sodium ethoxide in situ from sodium and an hydrous ethanol under a nitrogen blanket. Acetamidine hydrochloride and diethyl malonate are added and the reaction mixture heated to boiling for 2 to 5 hours to afford 4,6-dihydroxy-2-methylpyrimidine.